Suc-YVAD-pNA

Suc-YVAD-pNA is a colorimetric substrate for caspase-1/interleukin-1beta-converting enzyme (ICE) and caspase-4. Caspase-1 and caspase-4 preferentially bind to and cleave the Tyr-Val-Ala-Asp (YVAD) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of caspase-1 and caspase-4 activity.Formal Name: N-(3-carboxy-1-oxopropyl)-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-alpha-asparagine. CAS Number: 208264-84-0. Synonyms: Caspase-1 and Caspase-4 Chromogenic Substrate, Suc-Tyr-Val-Ala-Asp-p-nitroanilide. Molecular Formula: C31H38N6O12. Formula Weight: 686.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetic Acid (50%): soluble. lambdamax: 223, 317 nm. SMILES: O=C([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(CCC(O)=O)=O)CC1=CC=C(O)C=C1)=O)=O)=O)NC2=CC=C([N+]([O-])=O)C=C2. InChi Code: InChI=1S/C31H38N6O12/c1-16(2)27(36-30(46)22(34-24(39)12-13-25(40)41)14-18-4-10-21(38)11-5-18)31(47)32-17(3)28(44)35-23(15-26(42)43)29(45)33-19-6-8-20(9-7-19)37(48)49/h4-11,16-17,22-23,27,38H,12-15H2,1-3H3,(H,32,47)(H,33,45)(H,34,39)(H,35,44)(H,36,46)(H,40,41)(H,42,43)/t17-,22-,23-,27-/m0/s1. InChi Key: APPSYVHVOCTIDH-ZBBFOALVSA-N.