SU 5201

SU 5201 is an inhibitor of IL-2 production. It inhibits IL-2 production in peripheral blood mononuclear cells (PBMCs) with an IC50 value of 1 nM. SU 5201 also inhibits VEGF- or acidic FGF-induced proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations of 2.5 and 2.3 µM, respectively.Formal Name: 3-[(3,4-dichlorophenyl)methylene]-1,3-dihydro-2H-indol-2-one. CAS Number: 114727-43-4. Synonyms: NSC 247030. Molecular Formula: C15H9Cl2NO. Formula Weight: 290.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 20 mg/ml. lambdamax: 255, 326 nm. SMILES: O=C1NC2=C(C1=CC3=CC(Cl)=C(C=C3)Cl)C=CC=C2. InChi Code: InChI=1S/C15H9Cl2NO/c16-12-6-5-9(8-13(12)17)7-11-10-3-1-2-4-14(10)18-15(11)19/h1-8H,(H,18,19). InChi Key: RCJZXLNWNCVIMJ-UHFFFAOYSA-N.