Streptozocin

Description: Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. The product is unstable in solution and is recommended to be dispensed now. Target: Antibacterial, DNA Alkylation, Autophagy, Antibiotic, DNA/RNA Synthesis, DNA Alkylator/Crosslinker. Smiles: CN(N=O)C(=O)NC1C(O)OC(CO)C(O)C1O. References: Nahdi AMTA, et al. Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5F Pancreatic beta-Cells. Oxid Med Cell Longev. 2017,2017:7054272.