STF-118804

Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD+ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. STF-118804 is a small molecule inhibitor of Nampt (IC50s = 3-6 nM) that prevents NAD+ synthesis from nicotinamide. It inhibits the viability of multiple B-cell acute lymphoblastic leukemia (B-ALL) cell lines with nanomolar potency and induces apoptosis in MV4-11 cells. At 50 mg/kg for 20 days, STF-118804 has been shown to improve survival in an orthotopic xenotransplant model of high-risk ALL in mice. It has also been shown to target leukemia stem cells.Formal Name: 4-[5-methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)-benzamide. CAS Number: 894187-61-2. Molecular Formula: C25H23N3O4S. Formula Weight: 461.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.2 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 222, 300 nm. SMILES: CC1=CC=C(S(CC2=C(C)OC(C3=CC=C(C(NCC4=CN=CC=C4)=O)C=C3)=N2)(=O)=O)C=C1. InChi Code: InChI=1S/C25H23N3O4S/c1-17-5-11-22(12-6-17)33(30,31)16-23-18(2)32-25(28-23)21-9-7-20(8-10-21)24(29)27-15-19-4-3-13-26-14-19/h3-14H,15-16H2,1-2H3,(H,27,29). InChi Key: DLFCEZOMHBPDGI-UHFFFAOYSA-N.