ST034307

ST034307 is an inhibitor of adenylyl cyclase 1 (AC1), a membrane-bound AC, with an IC50 value of 2.3 µM for A23187-stimulated cAMP accumulation in HEK293 cells transfected with AC1. It also inhibits AC1 activation induced by forskolin (Cay-11018) or isoproterenol (Cay-15592) in vitro. It is selective for AC1 over other membrane-bound AC isoforms. ST034307 enhances the inhibition of AC1 by the µ-opioid receptor (MOR) agonist DAMGO (Cay-21553) in HEK293 cells transfected with AC1 and MOR. In a mouse model of inflammatory pain, ST034307 reduces hypersensitivity to touch in mouse hind paw (ED50 = 0.28 µg), which is blocked by forskolin.Formal Name: 6-chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one. CAS Number: 133406-29-8. Molecular Formula: C10H4Cl4O2. Formula Weight: 298.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 5 mg/ml. lambdamax: 230, 312 nm. SMILES: O=C1C2=CC(Cl)=CC=C2OC(C(Cl)(Cl)Cl)=C1. InChi Code: InChI=1S/C10H4Cl4O2/c11-5-1-2-8-6(3-5)7(15)4-9(16-8)10(12,13)14/h1-4H. InChi Key: NTDHYMSVCBGQJF-UHFFFAOYSA-N.