SSE1806

SSE1806 is a microtubule destabilizer. It inhibits tubulin polymerization in a cell-free assay when used at a concentration of 10 µM. SSE1806 inhibits the growth of MCF-7 breast cancer, HCT116 colon cancer, K562 leukemia, and KB-3-1 and paclitaxel-resistant KB-V1 cervical cancer cells (GI50s = 5.02, 2.01, 17.74, 1.29, and 1.74 µM, respectively), as well as induces apoptosis and cell cycle arrest at the G2/M phase in HCT116 cells.Formal Name: 11-(3-nitrophenyl)-2,3,7,8,9,11-hexahydro-[1,4]dioxino[2,3-b]acridin-10(6H)-one. Molecular Formula: C21H18N2O5. Formula Weight: 378.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Methanol: Soluble. lambdamax: 212 nm. SMILES: O=C1C2=C(NC(C=C(OCCO3)C3=C4)=C4C2C5=CC([N+]([O-])=O)=CC=C5)CCC1. InChi Code: InChI=1S/C21H18N2O5/c24-17-6-2-5-15-21(17)20(12-3-1-4-13(9-12)23(25)26)14-10-18-19(11-16(14)22-15)28-8-7-27-18/h1,3-4,9-11,20,22H,2,5-8H2. InChi Key: QIBBEPCCDJOQSF-UHFFFAOYSA-N.