SR8278

Description: SR8278 is an REV-ERBalpha antagonist(EC50 = 0.47 µM), blocking activation of the receptor by the synthetic agonist GSK 4112. Target: Others. Smiles: CCOC(=O)C1Cc2ccccc2CN1C(=O)c1ccc(SC)s1. References: Kojetin D , Wang Y , Kamenecka T M , et al. Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB[J]. Acs Chemical Biology, 2011, 6(2):131-134.