SR 3576

SR 3576 is a JNK3 inhibitor (IC50 = 7 nM). It is selective for JNK3 over JNK1 and p38 MAP kinase (IC50s = 0.17 and >20 µM, respectively). It inhibits c-Jun phosphorylation in INS-1 cells (IC50 = 1.3 µM).Formal Name: 3-[4-[[[(3-methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide. CAS Number: 1164153-22-3. Molecular Formula: C27H27N5O5. Formula Weight: 501.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 40 mg/ml. SMILES: CC1=CC=CC(NC(NC2=CN(C3=CC=CC(C(NC4=CC(OC)=C(OC)C(OC)=C4)=O)=C3)N=C2)=O)=C1. InChi Code: InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34). InChi Key: MTFAYLZZDJGFGV-UHFFFAOYSA-N.