SR 202

SR 202 is an antagonist of peroxisome proliferator-activated receptor gamma (PPARgamma) transcriptional activity induced by troglitazone (Cay-71750, IC50 = 140 µM) but not of basal PPARgamma activity. It is selective for PPARgamma, not affecting basal or agonist-induced transcriptional activity of PPARalpha, PPARbeta, or the farnesoid X receptor (FXR). It inhibits PPARgamma-dependent differentiation of preadipocyte 3T3-L1 cells in a dose-dependent manner. SR 202 (400 mg/kg) decreases the amount of weight gained and white adipose tissue mass accumulated by mice fed a standard or high-fat diet for ten weeks and is associated with lower PPARgamma mRNA levels. It protects against high-fat diet-induced insulin resistance in wild-type mice and improves insulin sensitivity in ob/ob mice.Formal Name: phosphoric acid, (4-chlorophenyl)(dimethoxyphosphinyl)methyl dimethyl ester. CAS Number: 76541-72-5. Molecular Formula: C11H17ClO7P2. Formula Weight: 358.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 100 mM. lambdamax: 226 nm. SMILES: ClC1=CC=C(C=C1)C(OP(OC)(OC)=O)P(OC)(OC)=O. InChi Code: InChI=1S/C11H17ClO7P2/c1-15-20(13,16-2)11(19-21(14,17-3)18-4)9-5-7-10(12)8-6-9/h5-8,11H,1-4H3. InChi Key: VQHUQHAPWMNBLP-UHFFFAOYSA-N.