SR 16584

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels in the central and peripheral nervous system. SR 16584 is an antagonist of the alpha3beta4 nAChR subtype (IC50 = 10.2 µM). It shows selective binding of the alpha3beta4 subtype compared to the alpha4beta2 and alpha7 subtypes (Ki values of 0.508, >100, and >100 µM, respectively), indicating that it should be a useful tool for receptor subtype studies.Formal Name: 3-dihydro-1-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-2H-indol-2-one. CAS Number: 1150153-86-8. Molecular Formula: C17H22N2O. Formula Weight: 270.4. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 0.3 mg/ml, DMSO: 0.2 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 205, 253 nm. SMILES: O=C(CC1=C2C=CC=C1)N2[C@@H]3C[C@H](N4C)CCC[C@H]4C3. InChi Code: InChI=1S/C17H22N2O/c1-18-13-6-4-7-14(18)11-15(10-13)19-16-8-3-2-5-12(16)9-17(19)20/h2-3,5,8,13-15H,4,6-7,9-11H2,1H3/t13-,14+,15-. InChi Key: GIDZCNCCCWFCIN-QDMKHBRRSA-N.