sPLA2-X Inhibitor 31

Description: sPLA2-X Inhibitor 31 is a selective inhibitor of secreted phospholipase A2 type X (sPLA2-X) with IC50 values of 26 nM for sPLA2-X, 310 nM for sPLA2-IIa, and 2230 nM for sPLA2-V. Target: Others. Smiles: C(N)(=O)C=1N(C=2C(C1)=CC=C(OC(F)(F)F)C2)C3=CC(CCC(O)=O)=CC=C3. References: Knerr L, et al. Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X(sPLA2-X) Inhibitors. ACS Med Chem Lett. 2018 Jun 23,9(7):594-599.