Spebrutinib besylate

Description: Spebrutinib besylate (AVL-292 benzenesulfonate, CC-292 besylate) is a Btk kinase activity inhibitor with an IC50 of less than 0.5 nM and a Kinact/Ki of 7.69×10^4 M^-1s^-1. Target: BTK. Smiles: O=C(C=C)NC1=CC=CC(=C1)NC2=NC(=NC=C2F)NC3=CC=C(OCCOC)C=C3.O=S(=O)(O)C=1C=CC=CC1. References: Evans EK, et al. Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans. J Pharmacol Exp Ther. 2013 Aug,346(2):219-28.