Sp-Cyclic AMPS (sodium salt)

Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases. Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF domain (EC50 = 40 µM). It has been used to study GAF-mediated stimulation of PDE10.Formal Name: cyclic 3',5'-[hydrogen (S)-phosphorothioate] adenosine, monosodium salt. CAS Number: 142439-95-0. Synonyms: Sp-cAMPS. Molecular Formula: C10H11N5O5PS . Na. Formula Weight: 367.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 25 mg/ml. lambdamax: 259 nm. SMILES: [S-][P@]1(OC[C@]2([H])[C@@]([C@@H](O)[C@H](N3C(N=CN=C4N)=C4N=C3)O2)([H])O1)=O.[Na+]. InChi Code: InChI=1S/C10H12N5O5PS.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7,/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13),/q,+1/p-1/t4-,6-,7-,10-,21+,/m1./s1. InChi Key: YTUKZYORDGLGPR-BIQAKYJPSA-M.