SP-13786

SP-13786 is an inhibitor of the protease fibroblast activation protein (FAP, IC50 = 3.2 nM). It is selective for FAP over prolyl endopeptidase, dipeptidyl peptidase 4 (DPP-4), DPP-9, and DPP-2 (IC50s = >1.8, >100, >12.5, and >100 µM, respectively). Nanoliposomes containing a PEGylated form of SP-13786 have been used to target cancer-associated fibroblasts (CAFs) in vitro and in vivo.Formal Name: N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-4-quinolinecarboxamide. CAS Number: 1448440-52-5. Synonyms: UAMC-1110. Molecular Formula: C17H14F2N4O2. Formula Weight: 344.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Sparingly Soluble: 1-10 mg/ml. SMILES: O=C(N1CC(F)(F)C[C@H]1C#N)CNC(C2=CC=NC3=C2C=CC=C3)=O. InChi Code: InChI=1S/C17H14F2N4O2/c18-17(19)7-11(8-20)23(10-17)15(24)9-22-16(25)13-5-6-21-14-4-2-1-3-12(13)14/h1-6,11H,7,9-10H2,(H,22,25)/t11-/m0/s1. InChi Key: PUOOCZVRHBHJRS-NSHDSACASA-N.