Sotrastaurin

Description: Sotrastaurin (AEB071) is a potent pan-PKC inhibitor with Kis of 0.95 nM for PKCalpha, 0.64 nM for PKCbetaI, 2.1 nM for PKCdelta, 3.2 nM for PKCepsilon, 1.8 nM for PKCeta, and 0.22 nM for PKCtheta. Target: PKC. Smiles: CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1. References: Evenou JP, et al. The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation. J Pharmacol Exp Ther. 2009 Sep,330(3):792-801.