SNT-207707 (hydrochloride)

SNT-207707 is a melanocortin receptor 4 (MC4R) antagonist (IC50 = 5 nM). It increases food intake in mice when administered at a dose of 20 mg/kg. SNT-207707 (30 mg/kg per day) inhibits tumor-induced weight loss without inhibiting tumor growth in a C26 murine colon carcinoma model of tumor-induced cachexia.Formal Name: 2-(4-cyanophenyl)-N,N-bis(3-methylbutyl)-3-[3-(1-pyrrolidinyl)propyl]-imidazo[1,2-a]pyridine-6-carboxamide, monohydrochloride. CAS Number: 1064662-40-3. Molecular Formula: C32H43N5O . HCl. Formula Weight: 550.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(C1=CN2C(CCCN3CCCC3)=C(C(C=C4)=CC=C4C#N)N=C2C=C1)N(CCC(C)C)CCC(C)C.Cl. InChi Code: InChI=1S/C32H43N5O.ClH/c1-24(2)15-20-36(21-16-25(3)4)32(38)28-13-14-30-34-31(27-11-9-26(22-33)10-12-27)29(37(30)23-28)8-7-19-35-17-5-6-18-35,/h9-14,23-25H,5-8,15-21H2,1-4H3,1H. InChi Key: FBNJDWPWZNPVSC-UHFFFAOYSA-N.