SNC 80

Description: SNC 80 (NIH 10815) is a potent, highly selective and non-peptide delta-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates µ-delta heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant-like effects. SNC80 has the potential for multiple headache disorders treatment. Target: Opioid Receptor. Smiles: CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1cccc(OC)c1. References: Moye LS, et al. Delta opioid receptor agonists are effective for multiple types of headache disorders. Neuropharmacology. 2019 Apr,148:77-86.