Sinapic Acid

Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities. Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM). It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 µg/ml, respectively. Sinapic acid (200 µM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold. It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively). In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil (Cay-14252) and bicuculline (Cay-11727). Sinapic acid is also commonly used as a matrix in protein mass spectrometry.Formal Name: 3-(4-hydroxy-3,5-dimethoxyphenyl)-2-propenoic acid. CAS Number: 530-59-6. Synonyms: NSC 59261, Sinapinic Acid. Molecular Formula: C11H12O5. Formula Weight: 224.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 240, 326 nm. SMILES: COC1=C(O)C(OC)=CC(/C=C/C(O)=O)=C1. InChi Code: InChI=1S/C11H12O5/c1-15-8-5-7(3-4-10(12)13)6-9(16-2)11(8)14/h3-6,14H,1-2H3,(H,12,13)/b4-3+. InChi Key: PCMORTLOPMLEFB-ONEGZZNKSA-N.