Simvastatin

Synthetic analog of Lovastatin (Prod. No. AG-CN2-0051), potent competitive HMG-CoA reductase inhibitor, anti-hypercholesterolemic agent, cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids, inhibits the isoprenylation of Ras and Rho family GTPases, smooth muscle cell proliferation inhibitor, anti-adhesive, immunomodulatory and anti-inflammatory compound, proteasome modulator, stimulates bone formation, apoptosis inducer, anticancer compound, increases cellular resistance to anticancer agents such as doxorubicin and etoposides (Prod. No. AG-CR1-3572), suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection, anti-hypertensive agent, suppresses TNF-induced NF-kappaB activation