SI-113

Description: SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades. Target: SGK. Smiles: C(=CC1=CC=CC=C1)N2C=3C(=C(NCCC4=CC=CC=C4)N=C(NCCO)N3)C=N2. References: Matteoni S, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17,38(1):202.