SGK1 inhibitor

Description: SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3beta in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kalpha inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719. Target: Others. Smiles: N(S(=O)(=O)C1=C(Cl)C(Cl)=CC=C1)C2=CC=C(C=3N=C4C(=NC3)C(N)=NN4)C=C2