Sergliflozin A

Sergliflozin A is an inhibitor of sodium-glucose cotransporter 2 (SGLT2, Ki = 2.39 nM for the human transporter) and an active metabolite of sergliflozin etabonate. It is formed from sergliflozin etabonate by esterases and selectively inhibits SGLT2 over SGLT1 (Ki = 708 nM for the human transporter). Co-infusion of sergliflozin A and glucose reduces maximal renal glucose reabsorption rates in rats.Formal Name: 2[(4methoxyphenyl)methyl]phenyl, beta-D-glucopyranoside. CAS Number: 360775-96-8. Molecular Formula: C20H24O7. Formula Weight: 376.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC2=C(CC3=CC=C(OC)C=C3)C=CC=C2. InChi Code: InChI=1S/C20H24O7/c1-25-14-8-6-12(7-9-14)10-13-4-2-3-5-15(13)26-20-19(24)18(23)17(22)16(11-21)27-20/h2-9,16-24H,10-11H2,1H3/t16-,17-,18+,19-,20-/m1/s1. InChi Key: HFLCZNNDZKKXCS-OUUBHVDSSA-N.