SD-2590 HCl

Description: SD-2590 HCl is an MMP-2,-3, -9, -8, 13, and -14 inhibitor. Target: Others. Smiles: Cl.O=C(NO)C1(CCN(CCOC)CC1)S(=O)(=O)C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2. References: Becker DP, Barta TE, Bedell LJ, Boehm TL, Bond BR, Carroll J, Carron CP, Decrescenzo GA, Easton AM, Freskos JN, Funckes-Shippy CL, Heron M, Hockerman S, Howard CP, Kiefer JR, Li MH, Mathis KJ, McDonald JJ, Mehta PP, Munie GE, Sunyer T, Swearingen CA, Villamil CI, Welsch D, Williams JM, Yu Y, Yao J. Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J Med Chem. 2010 Sep 23,53(18):6653-80. doi: 10.1021/jm100669j. PubMed PMID: 20726512.