Schisandrin A

Schisandrin A is a lignan that has been found in Schisandra and has diverse biological activities. It binds to adiponectin receptor 2 (IC50 = 3.2 µM). Schisandrin A (10, 20, and 50 µM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-alpha and apoptosis in primary mouse microglial cells. It reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells when used at a concentration of 20 µM. Schisandrin A (4, 12, and 36 mg/kg) reverses short-term and spatial memory deficits, as well as decreases in cerebral superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities induced by amyloid beta (1-42) (Abeta42, Cay-20574) in a mouse model of Alzheimer's disease.Formal Name: (6R,7S,12aR)-5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-dibenzo[a,c]cyclooctene. CAS Number: 61281-38-7. Synonyms: Deoxyschizandrin, Wuweizisu A. Molecular Formula: C24H32O6. Formula Weight: 416.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/mL, DMF:PBS (pH 7.2) (1:8): 0.11 mg/mL, DMSO: 20 mg/mL, Ethanol: 20 mg/mL. lambdamax: 217 nm. SMILES: COC(C(OC)=C1)=C(OC)C2=C1C[C@H](C)[C@H](C)CC3=C2C(OC)=C(OC)C(OC)=C3. InChi Code: InChI=1S/C24H32O6/c1-13-9-15-11-17(25-3)21(27-5)23(29-7)19(15)20-16(10-14(13)2)12-18(26-4)22(28-6)24(20)30-8/h11-14H,9-10H2,1-8H3/t13-,14+. InChi Key: JEJFTTRHGBKKEI-OKILXGFUSA-N.