SCH 39166 (hydrobromide)

SCH 39166 is a dopamine D1 receptor antagonist (Ki = 5 nM). It is selective for D1 over D2-4 receptors (Kis = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D5 receptors (Ki = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED50 = 0.84 mg/kg). It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake. SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.Formal Name: 11-chloro-7-methyl-6,6alphaS,7,8,9,13betaR-hexahydro-5H-benzo[d]naphtho[2,1-beta]azepin-12-ol, monohydrobromide. CAS Number: 1227675-51-5. Molecular Formula: C19H20ClNO . HBr. Formula Weight: 394.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble, Water: Slightly Soluble. SMILES: ClC(C(O)=C1)=CC2=C1[C@]3([H])[C@](N(C)CC2)([H])CCC4=CC=CC=C43.Br. InChi Code: InChI=1S/C19H20ClNO.BrH/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21,/h2-5,10-11,17,19,22H,6-9H2,1H3,1H/t17-,19+,/m0./s1. InChi Key: GAUWIDFICGEZKR-JUOYHRLASA-N.