SBI-115

SBI-115 is an antagonist of G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5. It inhibits taurolithocholic acid-induced increases in cAMP levels in, and proliferation of, cholangiocytes isolated from patients with autosomal dominant polycystic kidney disease when used at concentrations of 100 and 200 µM. SBI-115 (10 µM) decreases the viability of, and protein levels of GPBAR1 in, PANC-1 pancreatic cancer cells. In vivo, SBI-115 (80 mg/kg) prevents B. pseudocatenulatum-induced decreases in serum levels of IFN-gamma and IL-17A in a mouse model of collagen-induced arthritis.Formal Name: 5-chloro-2-(ethylsulfonyl)-4-pyrimidinecarboxylic acid 3-methylphenyl ester. CAS Number: 882366-16-7. Molecular Formula: C14H13ClN2O4S. Formula Weight: 340.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble. SMILES: O=C(C1=NC(S(=O)(CC)=O)=NC=C1Cl)OC2=CC=CC(C)=C2. InChi Code: InChI=1S/C14H13ClN2O4S/c1-3-22(19,20)14-16-8-11(15)12(17-14)13(18)21-10-6-4-5-9(2)7-10/h4-8H,3H2,1-2H3. InChi Key: IJPXOPBVXVPPEW-UHFFFAOYSA-N.