SB 277011A (hydrochloride)

SB 277011A is an antagonist of the dopamine D3 receptor (pKi = 8.0) that is at least 100-fold selective for D3 over other monoamine receptors (pKis = 6.0, 5.0, and 2, 5-HT1D and 5-HT1B respectively). It has high oral bioavailability and enters the central nervous system of the rat. SB 277011A has been shown to have potential benefits in animal models of schizophrenia and Parkinson's disease.Formal Name: N-[trans-4-[2-(6-cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide, dihydrochloride. CAS Number: 1226917-67-4. Molecular Formula: C28H30N4O . 2HCl. Formula Weight: 511.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 14 mg/ml, DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 230, 284 nm. SMILES: O=C(C1=C2C(C=CC=C2)=NC=C1)N[C@H](CC3)CC[C@@H]3CCN(C4)CCC5=C4C=CC(C#N)=C5.Cl.Cl. InChi Code: InChI=1S/C28H30N4O.2ClH/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27,,/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33),2*1H/t20-,24-,,. InChi Key: HEZIOTGUXSPDAK-ONAIBGCWSA-N.