SAR441255 (sodium salt)

SAR441255 is a peptide triple agonist of the glucagon-like peptide 1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR). It induces cAMP accumulation in HEK293 cells expressing human GLP-1R, GIPR, or GCGR (EC50s = 1.03, 0.73, and 1.01 pM, respectively). SAR441255 (1-30 µg/kg) reduces body weight in a mouse model of high-fat diet-induced obesity. It also reduces body weight and blood hemoglobin A1c (HbA1c) levels in high-fat diet-induced obese diabetic cynomolgus monkeys when administered at a dose of 11 µg/kg.Molecular Formula: C225H355N57O63 . XNa. Formula Weight: 4866.6. Purity: >95%. Formulation: (Request formulation change), A solid. Peptide Sequence: HXHGTFTSDLSKLK(gammaGlu-gammaGlu-palmitic acid)EEQRQXEFIEWLKAaGPPSXKPPPK-NH2 (X=2-Aminioisobutyric Acid). Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, Water: Slightly Soluble: 0.1-1 mg/ml. SMILES: O=C([C@@H](NC(CC[C@H](NC(CCCCCCCCCCCCCCC)=O)C(O)=O)=O)CCC(NCCCC[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(NC(C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CNC3=CC=CC=C32)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@H](C)C(NCC(N4[C@H](C(N5CCC[C@H]5C(N[C@H](C(NC(C(N[C@@H](CCCCN)C(N6[C@H](C(N7[C@H](C(N8[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CCC8)=O)CCC7)=O)CCC6)=O)=O)(C)C)=O)CO)=O)=O)CCC4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)(C)C)=O)=O)=O)=O)=O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC9=CC=CC=C9)NC([C@H]([C@H](O)C)NC(CNC([C@H](CC%10=CNC=N%10)NC(C(NC([C@H](CC%11=CNC=N%11)N)=O)(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)O.[Na]. InChi Code: InChI=1S/C225H355N57O63.Na/c1-20-22-23-24-25-26-27-28-29-30-31-32-39-75-171(291)247-151(218(341)342)79-87-172(292)248-150(217(339)340)78-86-170(290)238-96-51-46-67-141(252-197(319)152(103-122(3)4)259-191(313)140(66-44-49-94-228)253-204(326)160(117-283)266-199(321)154(105-124(7)8)261-201(323)159(111-179(303)304)264-205(327)161(118-284)268-212(334)182(129(13)287)274-203(325)156(107-131-60-37-34-38-61-131)265-211(333)181(128(12)286)272-173(293)115-241-187(309)158(110-134-114-237-121-244-134)271-221(345)223(14,15)275-186(308)136(230)109-133-113-236-120-243-133)189(311)255-144(80-88-175(295)296)194(316)256-145(81-89-176(297)298)193(315)254-143(76-84-168(231)288)192(314)250-142(69-52-97-239-222(234)235)190(312)257-148(77-85-169(232)289)206(328)276-224(16,17)219(343)269-147(83-91-178(301)302)196(318)262-155(106-130-58-35-33-36-59-130)202(324)273-180(125(9)21-2)210(332)258-146(82-90-177(299)300)195(317)263-157(108-132-112-240-137-63-41-40-62-135(132)137)200(322)260-153(104-123(5)6)198(320)251-139(65-43-48-93-227)188(310)246-127(11)185(307)245-126(10)184(306)242-116-174(294)278-98-55-72-165(278)214(336)279-99-54-71-164(279)209(331)267-162(119-285)207(329)277-225(18,19)220(344)270-149(68-45-50-95-229)213(335)281-101-56-73-166(281)216(338)282-102-57-74-167(282)215(337)280-100-53-70-163(280)208(330)249-138(183(233)305)64-42-47-92-226,/h33-38,40-41,58-63,112-114,120-129,136,138-167,180-182,240,283-287H,20-32,39,42-57,64-111,115-119,226-230H2,1-19H3,(H2,231,288)(H2,232,289)(H2,233,305)(H,236,243)(H,237,244)(H,238,290)(H,241,309)(H,242,306)(H,245,307)(H,246,310)(H,247,291)(H,248,292)(H,249,330)(H,250,314)(H,251,320)(H,252,319)(H,253,326)(H,254,315)(H,255,311)(H,256,316)(H,257,312)(H,258,332)(H,259,313)(H,260,322)(H,261,323)(H,262,318)(H,263,317)(H,264,327)(H,265,333)(H,266,321)(H,267,331)(H,268,334)(H,269,343)(H,270,344)(H,271,345)(H,272,293)(H,273,324)(H,274,325)(H,275,308)(H,276,328)(H,277,329)(H,295,296)(H,297,298)(H,299,300)(H,301,302)(H,303,304)(H,339,340)(H,341,342)(H4,234,235,239),/t125-,126+,127-,128+,129+,136-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,180-,181-,182-,/m0./s1. InChi Key: SIAQVHIUWOILNN-CMORBLGQSA-N.