Sanggenon C

Description: 1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. 2. Sanggenon C and O inhibited NO production and iNOS expression by suppressing NF-kappaB activity and IkappaBalpha activation, inhibited TNF-alpha -stimulated PMN-HSC adhesion and expression of VCAM-1 by suppressing the activation of NF-kappaB. Target: NF-kappaB. Smiles: CC(C)=CC[C@]12Oc3cc(O)c([C@H]4C=C(C)C[C@@H]([C@H]4C(=O)c4ccc(O)cc4O)c4ccc(O)cc4O)c(O)c3C(=O)[C@@]1(O)Oc1cc(O)ccc21. References: Huang H , Liu N , Zhao K , et al. Sanggenon C decreases tumor cell viability associated with proteasome inhibition[J]. Front Biosci, 2011, 3(4):1315-1325.