Salvinorin A Propionate

Salvinorin A propionate is a selective partial agonist at kappa1-opioid receptors (KOR) with a Ki value of 32.6 nM. It inhibits adenylate cyclase (EC50 = 4.7 nM) in HEK293 cells transfected with human KOR. It is selective for KORs over µ, delta, and ORL-1 opioid receptors and has no effect at serotonin, dopamine, muscarinic, or adrenergic receptors. In mice, salvinorin A propionate (13 µg, i.c.v.) reduces nociceptive responses in a radiant heat tail-flick assay, though not as potently as salvinorin A (Cay-11487).Formal Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-9-(1-oxopropoxy)-2H-naphtho[2,1-c]pyran-7-carboxylic acid, methyl ester. CAS Number: 689295-71-4. Synonyms: Divinorin A Propionate, Sal A Propionate, Sal-2-propionate, Salvinorinyl-2-propionate. Molecular Formula: C24H30O8. Formula Weight: 446.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetonitrile: 1 mg/ml, DMF: 2 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 1 mg/ml. lambdamax: 211, 258, 273 nm. SMILES: [H][C@@]12CC[C@@]([C@@]3([H])[C@@]1(C)C[C@@H](C4=COC=C4)OC2=O)(C)[C@H](C(OC)=O)C[C@H](OC(CC)=O)C3=O. InChi Code: InChI=1S/C24H30O8/c1-5-18(25)31-16-10-15(21(27)29-4)23(2)8-6-14-22(28)32-17(13-7-9-30-12-13)11-24(14,3)20(23)19(16)26/h7,9,12,14-17,20H,5-6,8,10-11H2,1-4H3/t14-,15-,16-,17-,20-,23-,24-/m0/s1. InChi Key: UPFVFWZGNRKYFG-ZWLNRFIDSA-N.