Salinosporamide A

Salinosporamide A is a natural proteasome inhibitor. It is a beta-lactone-gamma-lactam that irreversibly inhibits all three protease activities within the proteasome (IC50s = 3.5, 28, and 430 nM for beta5 (chymotrypsin), beta2 (macropain), and beta1 (C5) subunits, respectively), both in vitro and in vivo. Salinosporamide A has potential applications in cancer therapy, particularly in combination with other chemotherapeutics.Formal Name: (1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione. CAS Number: 437742-34-2. Synonyms: Marizomib, ML-858, NPI-0052. Molecular Formula: C15H20ClNO4. Formula Weight: 313.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C1[C@H](CCCl)[C@]([C@@]2([C@@H](O)[C@@]3([H])CCCC=C3)N1)(C)OC2=O. InChi Code: InChI=1S/C15H20ClNO4/c1-14-10(7-8-16)12(19)17-15(14,13(20)21-14)11(18)9-5-3-2-4-6-9/h3,5,9-11,18H,2,4,6-8H2,1H3,(H,17,19)/t9-,10+,11+,14+,15+/m1/s1. InChi Key: NGWSFRIPKNWYAO-SHTIJGAHSA-N.