Safingol hydrochloride

Description: Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a specific inhibitor of protein kinase C. It induces autophagy in solid tumor cells and cancer cell death by inhibiting the PKC and PI3-kinase pathways.BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor. Safingol hydrochloride inhibits PKC and PI3k. Target: PI3K, PKC. Smiles: C(CCCCCCCCCC CCCC)[C@@H]([C@H](CO)N)O.Cl. References: Tan KB,et al. In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia. J Control Release. 2012 Jun 10,160(2):290-8.