Saccharin 1-methylimidazole

Saccharin 1-methylimidazole is a chemical activator that has been commonly used in solid-phase synthesis of DNA and RNA oligonucleotides. It catalyzes the phosphoramidite coupling reaction of the 5' hydroxy of immobilized nucleosides and the amine group of nucleoside phosphoramidite. Saccharin 1-methylimidazole has been used to synthesize single-stranded DNA (ssDNA) oligonucleotides that are resistant to nuclease digestion.Formal Name: benzo[d]isothiazol-3(2H)-one 1,1-dioxide, 1-methyl-1H-imidazole. CAS Number: 482333-74-4. Molecular Formula: C7H5NO3S . C4H6N2. Formula Weight: 265.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5mg/mL, DMSO: 5mg/mL, Ethanol: 10mg/mL, PBS (pH 7.2): 10mg/mL. SMILES: O=S1(C2=CC=CC=C2C(N1)=O)=O.CN3C=CN=C3. InChi Code: InChI=1S/C7H5NO3S.C4H6N2/c9-7-5-3-1-2-4-6(5)12(10,11)8-7,1-6-3-2-5-4-6/h1-4H,(H,8,9),2-4H,1H3. InChi Key: DMSNKRPEUQVMNF-UHFFFAOYSA-N.