S-Sulfocysteine

S-Sulfocysteine is an NMDA receptor agonist. It is selective for the NMDA receptor over the AMPA receptor in radioligand binding assays (EC50s = 8.2 and 59 µM, respectively). S-Sulfocysteine (200 µM) is cytotoxic to primary mouse neuronal cells. It induces calcium influx and activates calpain-dependent degradation of the post-synaptic scaffolding protein gephyrin when used at a concentration of 100 µM. S-Sulfocysteine (2 mM) increases swimming and seizure-like movements, indicating neurodegeneration, in zebrafish larvae when administered three days post-fertilization. Urinary and plasma levels of S-sulfocysteine are increased in patients with molybdenum cofactor deficiency (MoCD), an inborn error of metabolism characterized by neurodegeneration and early childhood death.Formal Name: S-sulfo-L-cysteine. CAS Number: 1637-71-4. Synonyms: L-Cysteine S-Sulfate, L-S-Sulphocysteine, S-Sulfo-L-Cysteine. Molecular Formula: C3H7NO5S2. Formula Weight: 201.2. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/ml, DMSO: 3 mg/ml, Ethanol: insol, PBS (pH 7.2): 5 mg/ml. SMILES: OC([C@@H](N)CSS(=O)(O)=O)=O. InChi Code: InChI=1S/C3H7NO5S2/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/t2-/m0/s1. InChi Key: NOKPBJYHPHHWAN-REOHCLBHSA-N.