(S)-Ibuprofen

(S)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and a COX-1 and COX-2 inhibitor (IC50s = 2.6 and 1.53 µM, respectively). It inhibits NF-kappaB transactivation in a reporter assay using Jurkat T cells (IC50 = 61.7 µM). (S)-Ibuprofen reduces aggregation in platelet-rich plasma and washed isolated human platelets (IC50s = 88 and 0.6 µM, respectively). It decreases superoxide formation and beta-glucuronidase release induced by N-formyl-Met-Leu-Phe (fMLP, Cay-21495), as well as leukotriene B4 (LTB4, Cay-20110) formation induced by calcimycin (A23187, Cay-11016), in human polymorphonuclear (PMN) cells (IC50s = 0.50, 0.53, and 0.14 µM, respectively). (S)-Ibuprofen increases the latency to withdrawal in hot plate and tail-flick tests in mice (ED50s = 64 and 54 mg/kg, respectively), as well as reduces paw swelling in a mouse model of carrageenan-induced paw edema (ED50 = 57 mg/kg). Formulations containing (±)-ibuprofen have been used in the treatment of fever and mild-to-severe pain.Formal Name: alphaS-methyl-4-(2-methylpropyl)-benzeneacetic acid. CAS Number: 51146-56-6. Synonyms: Dexibuprofen, (+)-Ibuprofen. Molecular Formula: C13H18O2. Formula Weight: 206.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 220 nm. SMILES: OC([C@@H](C)C1=CC=C(CC(C)C)C=C1)=O. InChi Code: InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1. InChi Key: HEFNNWSXXWATRW-JTQLQIEISA-N.