(S)-Camptothecin

White solid. Soluble in DMSO, DMF or MeOH. Insoluble in water Potent anticancer compound, Cell permeable potent DNA topoisomerase I (Topo I) complex inhibitor, Potent apoptosis inducer, Binds reversibly to the DNA topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, consequently depleting cellular topoisomerase I, Prevents DNA re-ligation and therefore causes DNA damage which results in apoptosis, Inhibits mitochondrial topoisomerase I (mtTop1), Blocks the cell cycle at low dose and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes, Antiprotozoal and antimalarial compound, Inhibitor of HIV replication and of other viruses, Suppresses nitric oxide (NO) biosynthesis, Shown to suppress TNF-alpha-induced expression of the inflammasome and cyclooxygenase 2 (COX-2).