RX-518

RX-518 is an inhibitor of EGFR. It inhibits the growth of A431, H1975, and HCC827 cancer cells expressing wild-type EGFR, EGFR L858R/T790M, and EGFR del19, respectively (GI50s = 5, 10, and 689 nM, respectively).Formal Name: N-[3-[2-[[2,3-difluoro-4-[4-(2-hydroxyethyl)-1-piperazinyl]phenyl]amino]-8-quinazolinyl]phenyl]-2-propenamide. CAS Number: 1660963-42-7. Synonyms: CK-101, Olafertinib. Molecular Formula: C29H28F2N6O2. Formula Weight: 530.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml, Methanol: Slightly Soluble: 0.1-1 mg/ml. SMILES: FC1=C(F)C(NC2=NC3=C(C=CC=C3C4=CC=CC(NC(C=C)=O)=C4)C=N2)=CC=C1N5CCN(CC5)CCO. InChi Code: InChI=1S/C29H28F2N6O2/c1-2-25(39)33-21-7-3-5-19(17-21)22-8-4-6-20-18-32-29(35-28(20)22)34-23-9-10-24(27(31)26(23)30)37-13-11-36(12-14-37)15-16-38/h2-10,17-18,38H,1,11-16H2,(H,33,39)(H,32,34,35). InChi Key: IDRGFNPZDVBSSE-UHFFFAOYSA-N.