Ruboxistaurin hydrochloride

Description: Ruboxistaurin hydrochloride (LY 333531 hydrochloride) is an Isozyme-selective inhibitor of protein kinase C (PKC), competitively and reversibly inhibits PKCbetaI and PKCbetaII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCbeta over other PKC isozymes (IC50values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 µM for PKCeta, -delta, -gamma, -alpha, -epsilon and -zeta respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src). Target: PKC. Smiles: Cl.CN(C)CC1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21. References: Jirousek MR, et al. J Med Chem. 1996, 39(14):2664-71.