RU-505

RU-505 is an inhibitor of the interaction between amyloid-beta (Abeta) and fibrinogen, with a higher efficacy for inhibiting monomeric forms of Abeta bound to fibrinogen over oligomeric forms. In vitro, RU-505 (20 µM) normalizes fibrin clot formation that is disrupted when fibrinogen is bound to Abeta42. RU-505 (35 mg/kg) decreases the incidence of vessel occlusion in the Tg6799 transgenic mouse model of Alzheimer's disease. Chronic treatment with RU-505 (35 mg/kg, s.c., every other day for 3 months) decreases Abeta deposition in blood vessels and cortical fibrinogen infiltration and microgliosis in the brain of Tg6799 mice. In addition, it improves spatial memory in chronically treated Tg6799 mice compared with vehicle control mice.Formal Name: N-[2-(dimethylamino)ethyl]-2-(1,1-dimethylethyl)-7-(4-fluorophenyl)-N-(phenylmethyl)-pyrazolo[1,5-a]pyrimidine-5-carboxamide. CAS Number: 1314206-29-5. Molecular Formula: C28H32FN5O. Formula Weight: 473.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 245 nm. SMILES: CC(C)(C)C1=NN(C(C2=CC=C(F)C=C2)=CC(C(N(CCN(C)C)CC3=CC=CC=C3)=O)=N4)C4=C1. InChi Code: InChI=1S/C28H32FN5O/c1-28(2,3)25-18-26-30-23(17-24(34(26)31-25)21-11-13-22(29)14-12-21)27(35)33(16-15-32(4)5)19-20-9-7-6-8-10-20/h6-14,17-18H,15-16,19H2,1-5H3. InChi Key: GMFHHCFJJZWFBW-UHFFFAOYSA-N.