Rp-8-bromo-PET-Cyclic GMPS (sodium salt)

Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM). It less potently inhibits protein kinase A (Ki = 11 µM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50 = 25 µM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki = 1 µM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.Formal Name: 2-bromo-3,4-dihydro-3-[3,5-O-[(R)-mercaptophosphinylidene]-beta-D-ribofuranosyl]-6-phenyl-9H-imidazo[1,2-a]purin-9-one, monosodium salt. CAS Number: 185246-32-6. Synonyms: Rp-8-bromo-PET-cGMPS. Molecular Formula: C18H14BrN5O6PS . Na. Formula Weight: 562.3. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: soluble. SMILES: O[C@H]1[C@H](N2C(Br)=NC3=C2NC4=NC(C5=CC=CC=C5)=CN4C3=O)O[C@@]6([H])[C@@]1([H])O[P@@](OC6)([S-])=O.[Na+]. InChi Code: InChI=1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8,/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32),/q,+1/p-1/t10-,12-,13-,16-,31-,/m1./s1. InChi Key: SVMPQLHYWRTQCX-DBHVCDLJSA-M.