Rp-8-bromo-Cyclic GMPS (sodium salt)

8-bromo cGMP (Cay-15992) is a cell-permeable analog of cGMP that exhibits resistance to hydrolysis by phosphodiesterases. It preferentially activates cGMP-dependent protein kinase (cGK). Rp-8-bromo-Cyclic GMPS (Rp-8-bromo-cGMPS) is a cell-permeable cGMP analog that adds an equatorial exocyclic (Rp) sulfur substitution in the axial position of the cyclophosphate ring of 8-bromo-cGMP. Like 8-bromo-cGMP, Rp-8-bromo-cGMPS is resistant to hydrolysis by phosphodiesterases. This Rp isomer binds cGK without activating it, resulting in competitive inhibition. At 10 µM, it blocks the relaxation of rat tail arteries induced by the nitric oxide donor SIN-1 (Cay-82220).Formal Name: 8-bromo-guanosine cyclic 3',5'-[(R)-(hydrogen phosphorothioate)], monosodium salt. CAS Number: 208445-06-1. Synonyms: Rp-8-bromo-cGMPS. Molecular Formula: C10H10BrN5O6PS . Na. Formula Weight: 462.2. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: soluble. SMILES: O[C@H]1[C@H](N2C(Br)=NC3=C2N=C(N)NC3=O)O[C@H]4[C@H]1O[P@@](OC4)([S-])=O.[Na+]. InChi Code: InChI=1S/C10H11BrN5O6PS.Na/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(21-8)1-20-23(19,24)22-5,/h2,4-5,8,17H,1H2,(H,19,24)(H3,12,14,15,18),/q,+1/p-1/t2-,4-,5-,8-,23-,/m1./s1. InChi Key: CHTSSROWUAICIL-GMKUFTCMSA-M.