(-)-Ropivacaine-d7 (hydrochloride)

(-)-Ropivacaine-d7 is intended for use as an internal standard for the quantification of (-)-ropivacaine (Cay-21422) by GC- or LC-MS. (-)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (-)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 µL of an 8 mM solution is injected percutaneously into the sciatic nerve. (-)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (-)- and (±)-bupivacaine (Cay-16618). Formulations containing (-)-ropivacaine have been used as local anesthetics during surgery and childbirth.Formal Name: (S)-N-(2,6-dimethylphenyl)-1-(propyl-d7)piperidine-2-carboxamide, monohydrochloride. CAS Number: 1217667-10-1. Synonyms: (S)-Ropivacaine-d7. Molecular Formula: C17H19D7N2O . HCl. Formula Weight: 317.9. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble, Water: soluble. SMILES: CC1=CC=CC(C)=C1NC([C@H]2N(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])CCCC2)=O.Cl. InChi Code: InChI=1S/C17H26N2O.ClH/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3,/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20),1H/t15-,/m0./s1/i1D3,4D2,11D2,. InChi Key: NDNSIBYYUOEUSV-JRDUKJLFSA-N.