Risperidone

Risperidone is an atypical antipsychotic that binds to dopamine D2 receptors (Ki = 3 nM) and the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 0.12 nM). It also binds to dopamine D4, alpha1- and alpha2-adrenergic, 5-HT1C, 5-HT1D, and histamine H1 receptors (Kis = 7, 0.81, 7.3, 47, 52, and 2.1 nM, respectively). Risperidone (0.1 mg/kg per day, i.p.) attenuates deficits in prepulse inhibition of the acoustic startle response, but not deficits in social interaction, in a rat neonatal ventral hippocampal lesion model of schizophrenia. Formulations containing risperidone have been used in the treatment of schizophrenia and bipolar disorder.Formal Name: 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one. CAS Number: 106266-06-2. Synonyms: Apexidone, Psychodal, R 64766. Molecular Formula: C23H27FN4O2. Formula Weight: 410.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.1 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 2 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 237, 279 nm. SMILES: FC1=CC=C2C(C3CCN(CCC4=C(C)N=C(CCCC5)N5C4=O)CC3)=NOC2=C1. InChi Code: InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3. InChi Key: RAPZEAPATHNIPO-UHFFFAOYSA-N.