Rimiducid

Rimiducid is a chemical inducer of dimerization (CID) for fusion proteins of the FK506 binding protein (FKBP) mutant FKBPF36V. It selectively binds to FKBPF36V over wild-type FKBP (IC50s = 0.005 and >10 µM, respectively). Rimiducid induces apoptosis in HT-1080 fibrosarcoma cells expressing a FKBPF36V fusion protein with the intracellular domain of Fas, also known as CD95, that contains a myristoylation sequence (EC50 = ~0.1 nM). It also induces apoptosis in primary human T lymphocytes expressing a FKBPF36V-Fas fusion protein (IC50 = ~0.2 nM). Rimiducid decreases serum human growth hormone (hGH) levels in mice injected with HT-1080 cells expressing FKBPF36V-Fas that constitutively secrete hGH, indicating conditional cell ablation (ED50 = 0.4 mg/kg).Formal Name: 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylic acid, (2S,2'S)-2,2'-[1,2-ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] ester. CAS Number: 195514-63-7. Synonyms: AP1903. Molecular Formula: C78H98N4O20. Formula Weight: 1411.6. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: soluble. SMILES: O=C(N1[C@@H](CCCC1)C(O[C@@H](C2=CC(OCC(NCCNC(COC3=CC([C@@H](CCC4=CC(OC)=C(C=C4)OC)OC([C@H]5N(CCCC5)C([C@H](C6=CC(OC)=C(C(OC)=C6)OC)CC)=O)=O)=CC=C3)=O)=O)=CC=C2)CCC7=CC(OC)=C(C=C7)OC)=O)[C@H](C8=CC(OC)=C(C(OC)=C8)OC)CC. InChi Code: InChI=1S/C78H98N4O20/c1-13-57(53-43-67(93-7)73(97-11)68(44-53)94-8)75(85)81-37-17-15-25-59(81)77(87)101-61(31-27-49-29-33-63(89-3)65(39-49)91-5)51-21-19-23-55(41-51)99-47-71(83)79-35-36-80-72(84)48-100-56-24-20-22-52(42-56)62(32-28-50-30-34-64(90-4)66(40-50)92-6)102-78(88)60-26-16-18-38-82(60)76(86)58(14-2)54-45-69(95-9)74(98-12)70(46-54)96-10/h19-24,29-30,33-34,39-46,57-62H,13-18,25-28,31-32,35-38,47-48H2,1-12H3,(H,79,83)(H,80,84)/t57-,58-,59-,60-,61+,62+/m0/s1. InChi Key: GQLCLPLEEOUJQC-ZTQDTCGGSA-N.