RGFP966

HDAC3 is highly expressed in brain, and its activity has been associated with negative regulation of learning and memory processes. RGFP966 is a selective inhibitor of HDAC3 (IC50 = 0.08 µM) that does not affect other HDACs at concentrations up to 15 µM. At 10 mg/kg, RGFP966 can facilitate the extinction of cocaine-seeking behavior and enhance long-term object memory acquisition/consolidation in mice. At 10 µM, RGFP966 can also induce apoptosis of cutaneous T cell lymphoma cells by disrupting their DNA replication activity.Formal Name: (2E)-N-(2-amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide. CAS Number: 1357389-11-7. Molecular Formula: C21H19FN4O. Formula Weight: 362.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 245, 285 nm. SMILES: FC1=CC(N)=C(NC(/C=C/C2=CN(C/C=C/C3=CC=CC=C3)N=C2)=O)C=C1. InChi Code: InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+. InChi Key: BLVQHYHDYFTPDV-VCABWLAWSA-N.