Revefenacin

Description: Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease. Target: AChR. Smiles: CN(CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1)C(=O)c1ccc(CN2CCC(CC2)C(N)=O)cc1. References: Pulido-Rios MT, McNamara A, Obedencio GP,et al.In vivo pharmacological characterization of TD-4208, a novel lung-selective inhaled muscarinic antagonist with sustained bronchoprotective effect in experimental animal models[J].J Pharmacol Exp Ther. 2013 Aug,346(2):241-50.