Repaglinide

White to off-white powder. Soluble in DMSO (30mg/ml), DMF (30mg/ml) or ethanol (20mg/ml). Chemical. CAS: 135062-02-1. Formula: C27H36N2O4. MW: 452.59. Repaglinide is a metaglitinide antidiabetic agent. It is a potent short-acting insulin secretagogue that acts by closing ATP-sensitive potassium (KATP) channels in the plasma membrane of the pancreatic beta cell. It represents a new class of insulin secretagogues, structurally unrelated to sulphonylureas, which were developed for the treatment of type 2 diabetes. Repaglinide shows also antioxidant and anti-inflammatory properties.