Rebeccamycin

Rebeccamycin is an indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I. It is cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s range from 0.4-98 µM), producing single-strand breaks in the DNA of these tumor cells.Formal Name: 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione. CAS Number: 93908-02-2. Synonyms: BRN 4732638, NSC 359079. Molecular Formula: C27H21Cl2N3O7. Formula Weight: 570.4. Purity: >99%. Formulation: (Request formulation change), A lyophilisate. Solubility: DMF: Soluble, DMSO: Soluble. SMILES: O=C(NC1=O)C2=C1C(C(C=CC=C3Cl)=C3N4[C@]5([H])O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]5O)=C4C6=C2C7=C(C(Cl)=CC=C7)N6. InChi Code: InChI=1S/C27H21Cl2N3O7/c1-38-24-13(8-33)39-27(23(35)22(24)34)32-20-10(5-3-7-12(20)29)15-17-16(25(36)31-26(17)37)14-9-4-2-6-11(28)18(9)30-19(14)21(15)32/h2-7,13,22-24,27,30,33-35H,8H2,1H3,(H,31,36,37)/t13-,22-,23-,24-,27-/m1/s1. InChi Key: QEHOIJJIZXRMAN-QZQSLCQPSA-N.