Rebaudioside A

Rebaudioside A is a glucosylated steviol glycoside studied and used as a non-glycemic sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. Rebaudioside A is a alpha-glucosidase inhibitor with (IC50=35µg/ml) and can inhibit ATP-sensitive K+-channels. In vitro rebaudioside A stimulated the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner. It increases glucagon-like peptide 1 (GLP-1) secretion in a 2-dimensional mouse intestine model. Rebaudioside A is metabolized by gut microbiota to steviol. Rebaudioside A shows antioxidant activity on reducing cellular reactive oxygen species. It is an activator of Nrf2 and is a potential candidate hepatoprotective agent. Product References: (1) R. Abudula, et al., Metab.53, 1378 (2004) , (2) R. Abudula, et al., Diabetes Obes. Metab. 10, 1074 (2008) , (3) D.J. Brusick, Food Chem. Toxicol. 46, S83 (2008) , (4) M. Upreti, et al., Molecules 17, 4186 (2012) , (5) D. Ripken, et al., J. Agric. Food Chem. 62, 8365 (2014) , (6) N. van der Wielen, et al., J. Nutr. 146, 2429 (2016) , (7) D.H. Shin, et al., Diabetes Metab. J. 40, 283 (2016) , (8) B.R. Adari, et al., Food Chem. 200, 154 (2016) , (9) Y. Wang, et al., Eur. J. Pharmacol. 822, 128 (2018) Appearance: White powder. Solubility: Soluble in water (10mg/ml) or DMSO. Identity: InChi Key: HELXLJCILKEWJH-NCGAPWICSA-N Smiles: C=C1[C@@]2(O[C@H]3[C@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@H](O)[C@@H](CO)O3)C[C@]6(C1)CC[C@]7([H])[C@](C)(C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=O)CCC[C@@]7(C)[C@]6([H])CC2