RBC8

RBC8 is a small molecule inhibitor of the Ras-like GTPases RalA and RalB that prevents binding of the GTPase to the Ral-binding protein. RBC8 has been shown to prevent Ral-mediated spreading of murine embryonic fibroblasts, block anchorage-independent growth of H2122 and H358 lung cancer cell lines (IC50s = 3.5 and 3.4 µM, respectively), and inhibit the growth of H2122 lung cancer xenografts in mice (50 mg/kg i.p.).Formal Name: 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile. CAS Number: 361185-42-4. Molecular Formula: C25H20N4O3. Formula Weight: 424.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, DMSO:PBS(pH 7.2) (1:2): 0.33 mg/mL, Ethanol: 0.25 mg/mL. lambdamax: 252 nm. SMILES: NC1=C(C#N)C(C2=CC(OC)=CC=C2OC)C3=C(NN=C3C4=CC(C=CC=C5)=C5C=C4)O1. InChi Code: InChI=1S/C25H20N4O3/c1-30-17-9-10-20(31-2)18(12-17)21-19(13-26)24(27)32-25-22(21)23(28-29-25)16-8-7-14-5-3-4-6-15(14)11-16/h3-12,21H,27H2,1-2H3,(H,28,29). InChi Key: CLMQBVUFKIKYLU-UHFFFAOYSA-N.